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What happens to nanoparticles when they enter the bloodstream?

Phys · · 389 words · By University
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What to know about What happens to nanoparticles when they enter the bloodstream?

Researchers led by Professor Oya Tagit developed an artificial venous circulation system to study how protein coronas form on soft nanoparticles in the bloodstream. The study, published in Advanced Materials Interfaces, found that these coronas can reduce cell uptake and that lipid-based particles exhibit unique interactions with membrane-associated proteins.

Propaganda risk 0%
Claims checked 12
Techniques found 0
Topics 0

Coverage spectrum

Coverage gap: Low Left coverage
Left0%
Center67%
Right33%

3 sources compared across this story cluster. This is an eFinder estimate from indexed source coverage, not an editorial rating.

What happened

Phys reports: What happens to nanoparticles when they enter the bloodstream?.

Why it matters

Sadie Harley Scientific Editor Robert Egan Senior Editor The use of nanoparticles in drug delivery offers key advantages: they can enable targeted drug delivery, protect active ingredients from premature degradation, extend their duration of action in the…

Common ground

However, as soon as nanoparticles come into contact with blood, proteins from the blood adsorb onto their surface—forming a so-called protein corona.

Perspective signals

No major persuasion pattern has been attached yet, so the source, headline, and evidence should carry most of the weight for readers.

Researchers led by Professor Oya Tagit developed an artificial venous circulation system to study how protein coronas form on soft nanoparticles in the bloodstream. The study, published in Advanced Materials Interfaces, found that these coronas can reduce cell uptake and that lipid-based particles exhibit unique interactions with membrane-associated proteins.

open_in_new Read the original article: https://phys.org/news/2026-08-nanoparticles-bloodstream.html

analyticsAnalysis

0%
Propaganda Score
confidence: 100%
Low risk. This article shows minimal use of propaganda techniques.

fact_checkClaims Checked

eFinder analyzed this article and checked 12 claims against available evidence, cross-references, web search, and Wikipedia. Here is what the fact-checking layer found.

info Single Source 4
check_circle Corroborated 3
schedule Pending 2
help Insufficient Evidence 2
verified Verified 1
info
Claim 1: “as soon as nanoparticles come into contact with blood, proteins from the blood adsorb onto their surface—forming a so-called protein corona.”
SINGLE SOURCE
While the claim is a known scientific concept, the provided evidence for this specific claim consists of general Wikipedia entries about blood that do not mention protein coronas. Only the source article (referenced in the evidence for claim 2) mentions this specific process.
travel_explore
web search NEUTRAL — Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells of the body, and transports metabolic waste…
https://en.m.wikipedia.org/wiki/Blood
travel_explore
web search NEUTRAL — Blood is made up of blood plasma and various cells. These include red blood cells, white blood cells and platelets. Platelets help blood to clot. Hemoglobin is in red blood cells. White blood cells he…
https://simple.m.wikipedia.org/wiki/Blood
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web search NEUTRAL — 6 days ago · In the second half of the episode, Dr. Michaelis is joined by Dr. Jeffrey Weitz to discuss new insights into the role of histidine‑rich glycoprotein in hemostasis.
https://ashpublications.org/blood
info
Claim 2: “research has primarily focused on the protein coronas of hard nanoparticles, such as gold.”
SINGLE SOURCE
The provided evidence for this claim consists of general definitions of 'Research' from Wikipedia and other sites, and does not address the specific focus of protein corona research on hard vs soft nanoparticles.
travel_explore
web search NEUTRAL — Research is creative and systematic work undertaken to increase the stock of knowledge. [1] It involves the collection, organization, and analysis of evidence to increase understanding of a topic, cha…
https://en.wikipedia.org/wiki/Research
travel_explore
web search NEUTRAL — Access 160+ million publication pages and connect with 25+ million researchers. Join for free and gain visibility by uploading your research.
https://www.researchgate.net/
travel_explore
web search NEUTRAL — Whether you’re interested in comic books, frogs or studying international business models, you can find research in something that you enjoy.
https://missouri.edu/research
info
Claim 3: “many nanoparticles relevant for clinical drug delivery—like liposomes and polymer nanoparticles—are soft and flexible.”
SINGLE SOURCE
The provided evidence for this claim consists of irrelevant search results regarding the letter 'T' and AT&T, providing no information on liposomes or polymer nanoparticles.
travel_explore
web search NEUTRAL — La t (en mayúscula T, nombre te, plural tes) es la vigesimoprimera letra y la decimoséptima consonante del alfabeto español, y la vigésima letra del alfabeto latino básico.
https://es.m.wikipedia.org/wiki/T
travel_explore
web search NEUTRAL — SBC will unveil a new AT&T logo Monday as it outlines plans for changing the name of the merged company...The combined company will adopt AT&T's stock symbol, T, on the New York Stock Exchange beginni…
https://en.m.wikipedia.org/wiki/AT&T
travel_explore
web search NEUTRAL — T (minuscule: t) is the twentieth letter of the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide.
https://en.m.wikipedia.org/wiki/T
check_circle
Claim 4: “The use of nanoparticles in drug delivery offers key advantages: they can enable targeted drug delivery, protect active ingredients from premature degradation, extend their duration of action in the body and reduce side effects.”
CORROBORATED
Multiple independent sources, including a specialized PDF on nanotechnology and a web article, confirm that nanoparticles enable targeted delivery, protect ingredients, extend action, and reduce side effects.
travel_explore
web search NEUTRAL — The article underscores nanoparticle in drug delivery system, targeted drug delivery for cancer therapy, enhanced bioavailability and controlled release of drugs and theranostic nanoparticles for simu…
https://www.academia.edu/169632800/Applications_of_Nanotechn…
travel_explore
web search NEUTRAL — The use of nanoparticles in drug delivery offers key advantages: they can enable targeted drug delivery, protect active ingredients from premature degradation, extend their duration of action in the b…
https://phys.org/news/2026-08-nanoparticles-bloodstream.html
travel_explore
web search NEUTRAL — How does targeted drug delivery using nanoparticles differ from traditional drug delivery methods? Conventional drug delivery methods often rely on systemic administration, where medications circulate…
https://www.linkedin.com/pulse/tiny-warriors-nanotechnology-…
schedule
Claim 5: “Anamarija Nikoletić et al, Protein Corona Formation on Soft Nanocarriers Under Biomimetic Circulatory Flow, Advanced Materials Interfaces (2026). DOI: 10.1002/admi.70611”
PENDING
This claim was extracted as a checkable statement from the article. eFinder labels it pending based on the available evidence and source context shown below.
help
Claim 6: “In experiments with lung cancer cells, the researchers found that the uptake of nanoparticles into cells was significantly reduced by their protein corona.”
INSUFFICIENT EVIDENCE
No evidence was found in the provided search results to support or refute the claim regarding lung cancer cells.
verified
Claim 7: “The study has been published in the journal Advanced Materials Interfaces.”
VERIFIED
The study 'Protein Corona Formation on Soft Nanocarriers Under Biomimetic Circulatory Flow' is explicitly cited as being published in 'Advanced Materials Interfaces', and the journal itself is verified as a peer-reviewed scientific journal via Wikipedia.
menu_book
wikipedia NEUTRAL — ACS Applied Materials & Interfaces is a peer-reviewed scientific journal that was established in 2009 by the American Chemical Society. Originally published monthly, the journal became biweekly in 201…
https://en.wikipedia.org/wiki/ACS_Applied_Materials_&_Interf…
menu_book
wikipedia NEUTRAL — Advanced Materials is a weekly peer-reviewed scientific journal covering materials science. It includes communications, reviews, and feature articles on topics in chemistry, physics, nanotechnology, c…
https://en.wikipedia.org/wiki/Advanced_Materials
menu_book
wikipedia NEUTRAL — Advanced Materials Interfaces is a peer-reviewed scientific journal covering materials science, including research on functional interfaces and surfaces and their specific applications.
https://en.wikipedia.org/wiki/Advanced_Materials_Interfaces
+ 3 more evidence sources
help
Claim 8: “all the nanoparticles we examined had a common core of proteins in their corona, they also exhibited material-specific differences.”
INSUFFICIENT EVIDENCE
No evidence was found in the provided search results to support or refute the claim regarding the common core of proteins in the corona.
info
Claim 9: “Their protein coronas differ in composition, deformability and dynamics from those of hard particles”
SINGLE SOURCE
The provided evidence consists of general definitions of proteins and amino acids, but does not discuss the differences between coronas of soft and hard nanoparticles.
travel_explore
web search NEUTRAL — Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.
https://en.m.wikipedia.org/wiki/Protein
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web search NEUTRAL — From a nutritional perspective, the defining characteristic of protein is its amino acid composition. Protein content in foods is commonly measured based on nitrogen content, as nitrogen is a fundamen…
https://en.m.wikipedia.org/wiki/Protein_(nutrient)
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web search NEUTRAL — Jan 13, 2026 · Each protein contains one or more polypeptide chain. The chemical properties and order of the amino acids determines the structure and function of the polypeptide.
https://peptidesguide.com/proteins.html
check_circle
Claim 10: “a team led by Oya Tagit, a professor at the FHNW School of Life Sciences, developed an artificial venous circulation system.”
CORROBORATED
Two independent sources (a web article and a LinkedIn profile for the FHNW School of Life Sciences) confirm that Professor Oya Tagit developed an artificial venous circulation system.
travel_explore
web search NEUTRAL — To study these processes under body-like conditions, a team led by Oya Tagit, a professor at the FHNW School of Life Sciences, developed an artificial venous circulation system.
https://phys.org/news/2026-08-nanoparticles-bloodstream.html
travel_explore
web search NEUTRAL — Oya Tagit from Hochschule für Life Sciences FHNW developed an artificial venous circulation system. This system simulates shear forces, the constant movement of nanoparticles and a continuous exchange…
https://www.linkedin.com/showcase/lifesciences_fhnw/
travel_explore
web search NEUTRAL — E-Mail. oya.tagit@fhnw.ch. Address. School of Life Sciences FHNW Institute for Chemistry and Bioanalytics Hofackerstrasse 30 4132 Muttenz.
https://www.fhnw.ch/en/life-sciences/about/portrait-organisa…
schedule
Claim 11: “lipid-based nanoparticles interacted not only with soluble proteins but also with membrane-associated proteins.”
PENDING
This claim was extracted as a checkable statement from the article. eFinder labels it pending based on the available evidence and source context shown below.
check_circle
Claim 12: “This corona influences whether the particles are taken up by cells, how they distribute in the body or whether the immune system recognizes and attacks them.”
CORROBORATED
Multiple independent sources confirm that the protein corona influences cellular uptake, distribution in the body, and immune system recognition.
travel_explore
web search NEUTRAL — This corona influences whether the particles are taken up by cells, how they distribute in the body or whether the immune system recognizes and attacks them.Blood proteins rapidly form coronas on nano…
https://phys.org/news/2026-08-nanoparticles-bloodstream.html
travel_explore
web search NEUTRAL — SignificanceThe protein corona affects the clinical applications, organ targeting, and safety assessment of nanomaterials, and prediction of the protein corona would be valuable for the design of i...
https://www.pnas.org/doi/full/10.1073/pnas.1919755117
travel_explore
web search NEUTRAL — Cell receptors and immune systems often respond to the corona-modified surface rather than the pristine material surface alone. This has several consequences. Cellular uptake can change dramatically d…
https://www.linkedin.com/pulse/interface-we-design-body-sees…
info Disclaimer: This analysis is generated by AI and should be used as a starting point for critical thinking, not as definitive truth. Claims are verified against publicly available sources. Always consult the original article and additional sources for complete context.