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Particle-by-particle tracking reveals uneven nanoparticle drug release

Phys · · 621 words · By Institute

Researchers from ICMAB-CSIC and other institutions have developed a method using dSTORM microscopy to track drug release from individual nanoparticles. This approach reveals that nanoparticle behavior is non-homogeneous, providing more precise data than traditional average-based measurements to help optimize future nanomedicine therapies.

open_in_new Read the original article: https://phys.org/news/2026-05-particle-tracking-reveals-uneven-nanoparticle.html

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11 claims extracted and verified against multiple sources including cross-references, web search, and Wikipedia.

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verified
“a team led by the Institute of Materials Science of Barcelona (ICMAB-CSIC), in collaboration with the Institute for Advanced Chemistry of Catalonia (IQAC) and the University of Parma, has demonstrated that it is possible to follow the release process particle by particle.”
VERIFIED
The evidence from the paper 'STORM as a tool to track cargo release from polymeric nanocarriers...' explicitly demonstrates the first application of dSTORM to track protein release from individual PLGA nanocapsules with nanometric precision, confirming the particle-by-particle tracking capability.
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web search NEUTRAL — researchers from The Arctic University.
https://www.tandfonline.com/doi/full/10.1080/22423982.2022.2…
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web search NEUTRAL — Here, we demonstrate the first application of direct stochastic optical reconstruction microscopy (dSTORM) to temporally and spatially track protein release from individual poly(lactic-co-glycolic aci…
https://pubs.rsc.org/en/content/articlehtml/2026/nh/d5nh0085…
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web search NEUTRAL — Stubborn cancer tumors were completely (and safely) eliminated in a mouse model with a small but mighty treatment method using nanoparticles, controlled drug release in stages, and light from lasers.
https://www.asiaresearchnews.com/content/nanoparticles-overc…
verified
“The study has been published in the journal Nanoscale Horizons in co-leadership with Sílvia Pujals from IQAC.”
VERIFIED
The evidence confirms the study was published in 'Nanoscale Horizons' (Royal Society of Chemistry) and identifies Sílvia Pujals as a researcher at the Institute of Advanced Chemistry of Catalonia (IQAC) involved in drug delivery systems.
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web search NEUTRAL — The particle-by-particle analysis revealed a rapid. This journal is © The Royal Society of Chemistry 2026.Nanoscale Horizons. release of the protein up to 4 days, followed by a sustained regime, achie…
https://pubs.rsc.org/en/content/articlepdf/2026/nh/d5nh00855…
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web search NEUTRAL — Sílvia Pujals. Spanish National Research Council | CSIC · Institute of Advanced Chemistry of Catalonia.In the field of drug delivery there has been a continuous study of powerful delivery systems to a…
https://www.researchgate.net/profile/Silvia-Pujals
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web search NEUTRAL — Find articles by Silvia Pujals. 1,* Editors: Maria Letizia Manca, Jose Luis Arias Mediano.The use of nanoscale materials imparts numerous advantages for both diagnosis and treatment, further leading t…
https://pmc.ncbi.nlm.nih.gov/articles/PMC8838478/
verified
“The team worked with nanocarriers based on a biodegradable polymer called PLGA, widely used in medical applications.”
VERIFIED
The source 'STORM as a tool to track cargo release from polymeric nanocarriers...' explicitly mentions the use of poly(lactic-co-glycolic acid) (PLGA) nanocapsules.
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web search NEUTRAL — Take online courses on Study.com that are fun and engaging. Pass exams to earn real college credit. Research schools and degrees to further your education.
https://study.com/
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web search NEUTRAL — Master any subject with Studley AI. Trusted by more than 2,000,000 top students. Create beautiful and interactive notes, flashcards, quizzes and podcasts from any content. Study smarter, not harder.
https://www.studley.ai/
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info
“In this study, a common protein called albumin was encapsulated and used as a model drug.”
SINGLE SOURCE
While the evidence confirms the study tracked 'protein release' from PLGA nanocarriers, the specific mention of 'albumin' as the model drug is not explicitly detailed in the provided snippets, although it is consistent with the study's focus on proteins.
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web search NEUTRAL — This study represents the first application of super-resolution microscopy to spatially and temporally resolve protein release from nanocarriers, offering single-molecule sensitivity and nanometric re…
https://pubs.rsc.org/en/content/articlehtml/2026/nh/d5nh0085…
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web search NEUTRAL — PLGA nanoparticles exhibit demonstrated versatility in accommodating hydrophobic or hydrophilic substances, which can be either encapsulated within their core matrix or adsorbed onto the surface. This…
https://www.frontiersin.org/journals/pharmacology/articles/1…
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web search NEUTRAL — PLGA is the most commonly used polymer as the inner polymeric core in preparing lipid-polymer hybrid nanoparticles [58]. The designing of lipid-PLGA nanoparticles depends on the optimal therapeutic ef…
https://pmc.ncbi.nlm.nih.gov/articles/PMC9786338/
verified
“the researchers applied the microscopy technique known as dSTORM, which allows individual fluorescent molecules to be localized with high precision.”
VERIFIED
The evidence explicitly states the application of 'direct stochastic optical reconstruction microscopy (dSTORM)' to track release with nanometric precision, and general sources confirm dSTORM's ability to localize individual molecules.
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web search NEUTRAL — Conventional fluorescence microscopy is performed by selectively staining the sample with fluorescent molecules, either linked to antibodies as in immunohistochemistry or using fluorescent proteins ge…
https://en.wikipedia.org/wiki/Photoactivated_localization_mi…
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web search NEUTRAL — Localization microscopy techniques are super-resolution fluorescence imaging methods based on the detection of individual molecules.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3460839/
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web search NEUTRAL — By using PA-FPs, you can activate only a few molecules at a time, which keeps signals from overlapping and lets you localize them accurately. Since researchers fuse these proteins to proteins of inter…
https://www.ico-optics.org/photoactivated-localization-micro…
verified
“By using different fluorescent labels of the nanocarrier and the encapsulated protein, they were able to observe both components simultaneously and follow their evolution over 30 days.”
VERIFIED
The evidence specifies the use of Cy5 for nanocarriers and AF488 for the protein, noting they are spectrally separated for dSTORM imaging, and mentions the protein release was achieved within 30 days.
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wikipedia NEUTRAL — The .30-30 Winchester / 7.62×52mmR (officially named the .30 Winchester Center Fire or .30 WCF) cartridge was first marketed for the Winchester Model 1894 lever-action rifle in 1895. The .30-30 (prono…
https://en.wikipedia.org/wiki/.30-30_Winchester
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wikipedia NEUTRAL — 30 may refer to: 30 (number), the natural number following 29 and preceding 31 one of the years 30 BC, AD 30, 1930, 2030
https://en.wikipedia.org/wiki/30
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wikipedia NEUTRAL — 30 for 30 is a series of documentary films airing on ESPN, its sister networks, and online highlighting interesting people and events in sports history. This includes four "volumes" of 30 episodes eac…
https://en.wikipedia.org/wiki/30_for_30
+ 3 more evidence sources
verified
“The results show an initial rapid release during the first days, followed by a more sustained phase until the polymer's final degradation.”
VERIFIED
The evidence from the study explicitly describes a 'rapid release of the protein up to 4 days, followed by a sustained regime, achieving complete protein release within 30 days'.
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web search NEUTRAL — Abnormal or misfolded proteins are degraded more rapidly, often by the Proteasome, which is a large protein assembly itself. These proteins are degraded either due to being targeted (Ubiquitin ligases…
https://en.wikipedia.org/wiki/Protein
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web search NEUTRAL — Bi-phasic release profiles from photo-cross-linked Pluronic hydrogels were observed. At an early stage, a burst-free and rapidly controlled release pattern was observed. A much slower sustained releas…
https://www.academia.edu/77626559/Photo_crosslinkable_thermo…
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web search NEUTRAL — Releasing a protein according to a zero-order profile without protein denaturation during the polymeric microparticle degradation process is very challenging.
https://www.researchgate.net/publication/7814720_Measurement…
info
“the nanoparticles show an increase in diameter and a decrease in number, indicating processes of hydration, swelling and degradation.”
SINGLE SOURCE
The provided evidence for the specific study mentions particle-by-particle analysis, but the specific details regarding the increase in diameter and decrease in number are not explicitly quoted in the snippets, although they are typical of PLGA degradation.
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web search NEUTRAL — Reduced skin friction decreases as nanoparticle diameter increases, influenced by nanofluid concentration. The reduced Nusselt number exhibits complex behavior based on the magnetic field and nanopart…
https://www.academia.edu/143184591/Magnetohydrodynamic_Flow_…
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web search NEUTRAL — In this study, Ag–Fe bimetallic nanoparticles were synthesized through a green approach using H. perforatum leaf extract and incorporated into electrospun GEL/CTS nanofibrous scaffolds for potential w…
https://pubs.rsc.org/en/content/articlehtml/2026/ra/d6ra0156…
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web search NEUTRAL — Figure 3 Diameter depending on the differential number (%) at different pH values: 2.63 (a), 3.60 (b), 4.25 (c), 5.90 (d), 7.25 (e), 8.07 (f), and 9.05 (g). The size comparison showed that the solutio…
https://www.scielo.br/j/rmat/a/TPqXMWLs3yKFCyz3cb33Q3x/?lang…
info
“While some release a significant part of the cargo quickly, others retain most of it for longer.”
SINGLE SOURCE
The study mentions 'capturing heterogeneity that ensembl[e]... [methods miss]', which supports the claim of heterogeneous release rates, but the specific phrasing is not fully corroborated by the snippets.
help
“The work forms part of Solé's doctoral thesis”
INSUFFICIENT EVIDENCE
No evidence was found in the search results regarding Anna Solé or her doctoral thesis.
schedule
“Anna Solé-Porta et al, STORM as a tool to track cargo release from polymeric nanocarriers at the single-particle level, Nanoscale Horizons (2026). DOI: 10.1039/d5nh00855g”
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info Disclaimer: This analysis is generated by AI and should be used as a starting point for critical thinking, not as definitive truth. Claims are verified against publicly available sources. Always consult the original article and additional sources for complete context.