Nickel catalyst enables precision mirror-image assembly for key drug scaffolds
A research team led by Prof. Sangwon Seo developed a nickel catalyst technology to synthesize β-methylene carbonyl derivatives as mirror-image isomers, which are critical for pharmaceutical applications. The method enables precise molecular assembly with potential impacts on drug development and precision chemistry.
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Read the original article: https://phys.org/news/2026-04-nickel-catalyst-enables-precision-mirror.html
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fact_checkFact-Check Results
11 claims extracted and verified against multiple sources including cross-references, web search, and Wikipedia.
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“A research team led by Prof. Sangwon Seo of the Department of Physics and Chemistry at DGIST has developed a catalytic technology that can easily and elaborately assemble key structural frameworks that serve as the scaffold of bioactive compounds.”
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“Using an abundantly available and inexpensive nickel (Ni) catalyst, the team has successfully synthesized β-methylene carbonyl derivatives, which form the core framework of many pharmaceuticals, exclusively in a single mirror-image isomer form.”
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“The β-methylene carbonyl is an extremely useful molecular framework widely found in numerous new drug candidates and natural products.”
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“Prior methods for imparting specific stereochemistry to this scaffold have been extremely limited, typically requiring application of strong bases or prior installation of complex auxiliary groups onto the substrates.”
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“Prof. Seo's research team focused on nickel, an earth-abundant transition metal, instead of expensive noble metals.”
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“The team developed a novel synthetic route that directly couples readily available chemical feedstocks (alkynes and carbonyl compounds).”
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“The nickel catalytic system realized near-perfect regioselectivity and enantioselectivity, ensuring precise molecular attachment and exclusive mirror-image formation.”
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“The reaction proceeds reliably to deliver only the desired transformation, even in complex structures or in the presence of diverse functional groups, without interference.”
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“The technology was successfully applied to precisely modify complex pharmaceutical structures and efficiently construct key scaffolds required for natural product synthesis.”
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“Through density functional theory (DFT)-based computational analysis, the team elucidated the mechanism by which the nickel catalyst controls bond formation and three-dimensional structure.”
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“The research is published in the journal Angewandte Chemie International Edition with DOI: 10.1002/anie.8854855.”
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