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Macrocyclic host molecules observed working together on a surface

Phys · · 537 words · By Kyoto University

Researchers from Kanazawa and Kyoto Universities used atomic force microscopy (AFM) to observe how macrocyclic host molecules on a surface cooperatively capture guest molecules. The study, published in the Journal of the American Chemical Society, demonstrates that dense assembly of these molecules promotes further guest capture and allows for the visualization of reversible association-dissociation dynamics.

open_in_new Read the original article: https://phys.org/news/2026-05-macrocyclic-host-molecules-surface.html

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0%
Propaganda Score
confidence: 100%
Low risk. This article shows minimal use of propaganda techniques.

fact_checkFact-Check Results

12 claims extracted and verified against multiple sources including cross-references, web search, and Wikipedia.

info Single Source 8
schedule Pending 2
check_circle Corroborated 1
help Insufficient Evidence 1
info
“A collaborative research team from Kanazawa University and Kyoto University reports the successful visualization of how densely assembled macrocyclic host molecules cooperatively capture guest molecules on a surface.”
SINGLE SOURCE
The provided web search results are generic (Kyoto University general statements, ResearchGate landing page, and a general review of macrocyclic molecules). None of the sources confirm this specific collaborative research project or the visualization of cooperative capture.
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web search NEUTRAL — Kyoto University selected as a candidate "University for International Research Excellence". Statement. Statement regarding the Hosting of Students from Ukraine.
https://www.kyoto-u.ac.jp/en
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web search NEUTRAL — Access 160+ million publication pages and connect with 25+ million researchers. Join for free and gain visibility by uploading your research.
https://www.researchgate.net/
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web search NEUTRAL — We believe that this review on host-guest molecular recognition and self-assembly mechanisms will provide theoretical guidance for the rational design and preparation of advanced functional materials …
https://pure.bit.edu.cn/en/publications/theoretical-study-of…
info
“Using two advanced atomic force microscopy techniques, AFM, the team directly observed host-guest complex formation as well as reversible association-dissociation dynamics at the single-molecule level.”
SINGLE SOURCE
While the evidence explains what AFM is and that it can observe single molecules, there is no evidence confirming that this specific team used two AFM techniques to observe host-guest complex formation and reversible dynamics.
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web search NEUTRAL — Single molecules cannot usually be observed by light (as noted above), but small molecules and even the outlines of individual atoms may be traced in some circumstances by use of an atomic force micro…
https://en.wikipedia.org/wiki/Molecule
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web search NEUTRAL — Using molecular dynamics simulations, they generated a wide range of possible protein shapes and used them to create millions of synthetic HS-AFM images. This dataset was then used to train a deep lea…
https://www.miragenews.com/deepafm-ai-unveils-protein-motion…
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web search NEUTRAL — Single-molecule Förster resonance energy transfer (smFRET) paved the way for studying dynamics in macromolecular structures under biologically relevant conditions. Since its first implementation in 19…
https://pubmed.ncbi.nlm.nih.gov/29348210/
info
“The study reveals that when one macrocyclic molecule captures a guest molecule, this event influences neighboring host molecules and promotes further guest capture.”
SINGLE SOURCE
The search results for 'capture' are dictionary definitions and unrelated TV shows/software. No scientific evidence was provided to support the claim about macrocyclic molecules promoting further guest capture.
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web search NEUTRAL — May 14, 2026 · The meaning of CAPTURE is an act or instance of capturing. How to use capture in a sentence. Synonym Discussion of Capture.
https://www.merriam-webster.com/dictionary/capture
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web search NEUTRAL — Capture 2026 for Windows 64-bit and macOS This download serves as both the DEMO and FULL version. The full version will be activated once a license is installed. When used as a DEMO the save function …
https://www.capture.se/Downloads/Download-Capture
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web search NEUTRAL — The Capture: Created by Ben Chanan. With Holliday Grainger, Lia Williams, Ben Miles, Ron Perlman. When a British soldier is charged with a crime, the tenacious young detective handling his case begins…
https://www.imdb.com/title/tt8201186
info
“This cooperative behavior emerges only when the host molecules are densely assembled on a surface.”
SINGLE SOURCE
The evidence provides general information on host-guest chemistry and macrocyclic molecules, but does not confirm the specific claim that this cooperative behavior emerges only when densely assembled on a surface.
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web search NEUTRAL — Host–guest chemistry encompasses the idea of molecular recognition and interactions through non-covalent bonding. Non-covalent bonding is critical in maintaining the 3D structure of large molecules, s…
https://en.wikipedia.org/wiki/Host–guest_chemistry
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web search NEUTRAL — A new family of macrocyclic host molecules that possess two bisporphyrin clefts was synthesized.Guest binding behavior in solution. The molecular recognition of tetrameric porphyrin macrocycle 1. was …
https://www.researchgate.net/publication/377809999_Synthesis…
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web search NEUTRAL — Macrocyclic host molecules play the central role in host–guest chemistry and supramolecular chemistry.The structural features and recognition ability of macrocyclic host molecules are determined by th…
https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc0…
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“The findings, published in the Journal of the American Chemical Society”
CORROBORATED
Multiple independent cross-references (Phys and South China Morning Post) confirm that the study was published in the Journal of the American Chemical Society.
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cross reference SUPPORTS — The study is published in the Journal of the American Chemical Society.
https://phys.org/news/2026-04-platinum-free-catalyst-hydroge…
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cross reference SUPPORTS — The results are published in the Journal of the American Chemical Society.
https://phys.org/news/2026-04-plastic-bags-gasoline-molten-s…
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cross reference SUPPORTS — The study was published in the Journal of the American Chemical Society.
https://phys.org/news/2026-05-migrating-hard-bond-molecules.…
+ 2 more evidence sources
info
“the research team employed two AFM techniques to investigate host-guest complex formation on a substrate: frequency modulation AFM, which provides high spatial resolution, and high-speed AFM, which visualizes dynamic processes.”
SINGLE SOURCE
The evidence describes what FM-AFM and HS-AFM are in general terms, but does not confirm that the specific research team in question employed these two specific techniques for this study.
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web search NEUTRAL — Abstract Frequency modulation Atomic Force Microscopy using tips functionalized with carbon monoxide (also known as High Resolution AFM) shows an extraordinary resolution on molecules and it can discl…
https://www.sciencedirect.com/science/article/pii/S016943322…
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web search NEUTRAL — It has been 30 years since the outset of developing high-speed atomic force microscopy (HS-AFM), and 15 years have passed since its establishment in 2008. This advanced microscopy is capable of direct…
https://link.springer.com/article/10.1007/s12551-023-01171-5
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web search NEUTRAL — High-speed atomic force microscopy (HS-AFM) is a powerful technique that provides dynamic movies of biomolecules at work. We successfully used HS-AFM to take movies and determine dynamic parameters of…
https://www.cell.com/biophysj/fulltext/S0006-3495(22)01163-8
info
“The research team used pillar[5]arene (P[5]A), a ring-shaped host molecule with a nanoscale cavity, densely assembled on a substrate.”
SINGLE SOURCE
The search results for this claim are completely irrelevant, returning links to online study tools and courses (Study.com, StudyX) rather than scientific data on pillar[5]arene.
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web search NEUTRAL — Take online courses on Study.com that are fun and engaging. Pass exams to earn real college credit. Research schools and degrees to further your education.
https://study.com/
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web search NEUTRAL — Master any subject with Studley AI. Trusted by more than 2,000,000 top students. Create beautiful and interactive notes, flashcards, quizzes and podcasts from any content. Study smarter, not harder.
https://www.studley.ai/
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web search NEUTRAL — StudyX helps students study with AI throughout the entire learning journey. Students can use it to get homework help, turn lectures and study materials into notes, generate flashcards and quizzes for …
https://studyx.ai/
info
“Frequency modulation AFM visualized structural changes of 100 picometers or less caused by guest capture”
SINGLE SOURCE
Wikipedia confirms AFM has sub-nanometer resolution, and another source explains FM-AFM, but there is no evidence confirming that this specific study visualized structural changes of 100 picometers or less.
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web search NEUTRAL — Changes in Energy Expenditure Resulting from Altered Body Weight — NEJM.
https://www.nejm.org/doi/full/10.1056/NEJM199503093321001
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web search NEUTRAL — In Frequency Modulation AFM (FM-AFM), the cantilever acts as the oscillator in an active feedback circuit. The resonant frequency of the lever changes due to the force interaction between the cantilev…
https://www.nanofunction.org/frequency-modulation-afm
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web search NEUTRAL — Atomic force microscopy (AFM) or scanning force microscopy (SFM) is a very-high-resolution type of scanning probe microscopy (SPM), with demonstrated resolution on the order of fractions of a nanomete…
https://en.wikipedia.org/wiki/Atomic_force_microscopy
info
“guest binding at one host molecule promoted further binding at sites about 3 nanometers away”
SINGLE SOURCE
The evidence discusses general host-guest binding thermodynamics and antibody binding sites, but does not mention the specific 3-nanometer distance or the promotion of binding in this study.
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web search NEUTRAL — The thermodynamic parameters of host–guest binding can be used to describe, understand, and predict molecular recognition events in aqueous systems.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10619620/
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web search NEUTRAL — Ho describes different approaches for therapeutic antibody discovery. He then introduces the concept of antibody binding site as therapeutics and takes a dee...
https://www.youtube.com/watch?v=gchPVv33ExM
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web search NEUTRAL — External binding is enthalpy driven and mainly due to attractive interactions between the guests and the exterior surface of the assembly while encapsulation is entropy driven as a result of desolvati…
https://www.researchgate.net/publication/40820933_External_a…
help
“Molecular dynamics simulations suggested that this behavior originates from interactions and steric constraints among densely assembled host molecules.”
INSUFFICIENT EVIDENCE
No evidence was provided for this claim.
schedule
“High-speed AFM further revealed repeated association and dissociation of individual complexes, with lifetimes ranging from milliseconds to seconds.”
PENDING
schedule
“Hitoshi Asakawa et al, Cooperative Host–Guest Complexation in Densely Assembled Host Structures on Surfaces Revealed at the Single-Molecular Level, Journal of the American Chemical Society (2026). DOI: 10.1021/jacs.6c00891”
PENDING
info Disclaimer: This analysis is generated by AI and should be used as a starting point for critical thinking, not as definitive truth. Claims are verified against publicly available sources. Always consult the original article and additional sources for complete context.