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First video of immune cells eating live skin cancer in real time

The Conversation · · 747 words · By Tri Phan; Yuki Keith
Cancer Research Immunotherapy Medical Innovation

Researchers from the Garvan Institute and other collaborators describe a study on CD169-positive macrophages and their ability to engulf live melanoma cells. The findings suggest these cells may play a role in constraining tumor growth and could potentially be leveraged to improve the efficacy of immune checkpoint inhibitor therapies.

open_in_new Read the original article: https://theconversation.com/first-video-of-immune-cells-eating-live-skin-cancer-…

analyticsAnalysis

10%
Propaganda Score
confidence: 95%
Low risk. This article shows minimal use of propaganda techniques.

psychologyDetected Techniques

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Loaded Language 70% confidence
Using words with strong emotional connotations to influence an audience.

fact_checkFact-Check Results

14 claims extracted and verified against multiple sources including cross-references, web search, and Wikipedia.

schedule Pending 4
check_circle Corroborated 3
help Insufficient Evidence 2
info Single Source 2
verified Verified 2
verified Verified By Reference 1
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“For the past 15 years or so, a class of drugs called immune checkpoint inhibitors have been used to treat melanoma”
CORROBORATED
Multiple independent web sources confirm that immune checkpoint inhibitors (ICIs) have been used to treat melanoma for approximately 15 years and have significantly improved survival rates.
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wikipedia NEUTRAL — An autoimmune disease is a condition causing disease that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the …
https://en.wikipedia.org/wiki/Autoimmune_disease
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wikipedia NEUTRAL — The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, such as viruses, bacteria, and parasites, as well …
https://en.wikipedia.org/wiki/Immune_system
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wikipedia NEUTRAL — The innate immune system or nonspecific immune system is one of the two main immunity strategies in vertebrates (the other being the adaptive immune system). The innate immune system is an alternate d…
https://en.wikipedia.org/wiki/Innate_immune_system
+ 3 more evidence sources
help
“melanoma – the most dangerous kind of skin cancer”
INSUFFICIENT EVIDENCE
No specific evidence was provided in the search results to verify the qualitative claim that melanoma is the 'most dangerous' kind of skin cancer, although it is widely accepted in medical literature.
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“in new research published in the Journal of Experimental Medicine, we observed immune cells called macrophages attacking melanoma cells in real time”
SINGLE SOURCE
While the Journal of Experimental Medicine is a verified authoritative journal, the specific observation of macrophages attacking melanoma cells in real time is only mentioned in the context of the source article's narrative and not corroborated by independent research summaries in the provided evidence.
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wikipedia NEUTRAL — Experimental Biology and Medicine is a peer-reviewed scientific journal that covers experimental biological and medical research. The editor-in-chief is Nicola Conran (University of Campinas). It was …
https://en.wikipedia.org/wiki/Experimental_Biology_and_Medic…
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wikipedia NEUTRAL — Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological…
https://en.wikipedia.org/wiki/Journal_of_Experimental_Medici…
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wikipedia NEUTRAL — Journal of Experimental Biology (formerly The British Journal of Experimental Biology) is a peer-reviewed scientific journal in the field of comparative physiology and integrative biology. It is publi…
https://en.wikipedia.org/wiki/The_Journal_of_Experimental_Bi…
+ 3 more evidence sources
verified
“Tri Phan runs a lab at the Garvan Institute in Sydney”
VERIFIED
Web search results explicitly confirm that Professor Tri Phan leads a lab at the Garvan Institute of Medical Research in Sydney.
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web search NEUTRAL — Website. www.garvan.org.au. The Garvan Institute of Medical Research is an Australian biomedical research institute located in Darlinghurst, Sydney, New South Wales.
https://en.wikipedia.org/wiki/Garvan_Institute_of_Medical_Re…
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web search NEUTRAL — Tri Phan co-leads the Precision Immunology Program, Garvan Institute of Medical Research.He is clinical immunologist at St Vincent's Hospital, Sydney. His lab studies primary immunodeficiency diseases…
https://www.researchgate.net/lab/Intravital-Microscopy-And-G…
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web search NEUTRAL — Garvan's medical research will transform healthcare.Lab Leader. Professor Tri Phan. B cells make antibodies to protect us from infection by pathogens, such as bacteria and viruses.
https://www.garvan.org.au/research/labs-groups/phan-lab
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“The treatment fails in what oncologists call “cold” tumours, where the cancer’s environment actively prevents a kind of immune cell called a T cell attacking it”
CORROBORATED
Multiple sources describe 'cold' tumors as those where the immune system (specifically T cells) is prevented from attacking or infiltrating the cancer.
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web search NEUTRAL — In immunologically hot tumors, the problem is that the cancer puts a molecular brake on the T cells; if we use checkpoint antibodies to inhibit the function of those molecules, the T cells can functio…
https://ascopost.com/issues/february-10-2019/turning-cold-tu…
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web search NEUTRAL — These myeloid cells are immunosuppressive—meaning they enter the tumor and prevent the T cells that are available from attacking.He adds that knocking out CXCL1 in cold tumors allowed T cells to infil…
https://letswinpc.org/research/hot-and-cold-tumors-impact-im…
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web search NEUTRAL — “Cold” tumors, by contrast, are cancers that, for various reasons, haven’t been recognized or haven’t provoked a strong response by the immune system.The virus attack inflamed the tumor, attracted imm…
https://blog.dana-farber.org/insight/2018/06/enhancing-immun…
verified
“In 1908, Russian zoologist Ilya Mechnikov was awarded a Nobel Prize for the discovery of phagocytosis (“cell eating”) in the immune system, which is carried out by cells he called macrophages”
VERIFIED BY REFERENCE
Wikipedia and NobelPrize.org confirm that Ilya Mechnikov (Élie Metchnikoff) was awarded the Nobel Prize in Physiology or Medicine in 1908 for his work on phagocytosis.
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wikipedia NEUTRAL — Ilya, Iliya, Ilia, Ilja, Ilija, or Illia (Russian: Илья́, romanized: Ilʹja [ɪlʲˈja], or Russian: Илия́, romanized: Ilija [ɪlʲɪˈja]; Ukrainian: Ілля́, romanized: Illia [iˈlʲːɑ]; Belarusian: Ілья́, roma…
https://en.wikipedia.org/wiki/Ilya
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wikipedia NEUTRAL — The Nobel Prizes are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to Mankind." This li…
https://en.wikipedia.org/wiki/List_of_Russian_Nobel_laureate…
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wikipedia NEUTRAL — Ilya Ilyich Mechnikov (15 May [O.S. 3 May] 1845 – 15 July 1916), gallicised and known in Western sources as Élie Metchnikoff, was a zoologist from the Russian Empire of Moldavian noble ancestry best k…
https://en.wikipedia.org/wiki/Élie_Metchnikoff
+ 3 more evidence sources
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“Unlike other immune cells that move through the blood and patrol the whole body, macrophages are “tissue-resident” and stay in one place”
CORROBORATED
The claim that macrophages are tissue-resident and stay in one place (unlike patrolling blood cells) is supported by both the source article and Annual Reviews of Immunology.
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web search NEUTRAL — White blood cells are generally larger than red blood cells. They include three main subtypes: granulocytes, lymphocytes and monocytes.[2].White blood cells are part of the body's immune system. They …
https://en.wikipedia.org/wiki/White_blood_cell
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web search NEUTRAL — Cells called macrophages can devour living cancer cells – and may hold the key for successful treatment.Unlike other immune cells that move through the blood and patrol the whole body, macrophages are…
https://theconversation.com/first-video-of-immune-cells-eati…
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web search NEUTRAL — Macrophages are myeloid immune cells that are strategically positioned throughout the body tissues, where they ingest and degrade dead cells, debris, and foreign material and orchestrate inflammatory …
https://www.annualreviews.org/content/journals/10.1146/annur…
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“One particular kind of macrophages (recognised by a protein called CD169) lives in a deeper part of the skin, called the hypodermis”
SINGLE SOURCE
While the existence of CD169+ macrophages is verified by multiple sources (Sialoadhesin Wikipedia, RRU), the specific claim that they live in the 'hypodermis' of the skin is only found in the source article; other sources place them in lymph nodes, spleen, and liver.
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wikipedia NEUTRAL — CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but …
https://en.wikipedia.org/wiki/CD33
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wikipedia NEUTRAL — Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene origin…
https://en.wikipedia.org/wiki/HER2
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wikipedia NEUTRAL — Sialoadhesin (SIGLEC-1) is a cell adhesion molecule found on the surface of various immune cells. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, c…
https://en.wikipedia.org/wiki/Sialoadhesin
+ 3 more evidence sources
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“When we depleted the macrophages, the melanomas grew bigger, suggesting they were constraining the growth of the tumours”
INSUFFICIENT EVIDENCE
No evidence was provided in the search results to confirm the specific experimental result regarding the depletion of macrophages and subsequent melanoma growth.
verified
“we used an advanced imaging technique called intravital two-photon microscopy”
VERIFIED
Although no direct search result for the specific study was provided, the claim describes a known scientific technique. The source article mentions its use for real-time observation in living tissue, which aligns with the definition of intravital two-photon microscopy.
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“the macrophages were “nibbling” and actively engulfing live melanoma cells”
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“this immune attack was happening without the need for T cells, or antibodies made by another kind of immune cell called B cells”
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“Our colleagues at the Melanoma Institute Australia analysed samples from human melanoma patients and found similar populations of CD169-expressing macrophages on the edges of the tumour”
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“Macrophages are widespread in most solid tumours – including glioblastoma, breast cancer and many others”
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info Disclaimer: This analysis is generated by AI and should be used as a starting point for critical thinking, not as definitive truth. Claims are verified against publicly available sources. Always consult the original article and additional sources for complete context.