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Cryo-EM imaging reveals how the body stops bleeding

Phys · · 475 words · By University

Researchers at the University of Leeds have used cryo-EM imaging to visualize the structure of platelet myosin and identify how it remains inactive until needed for blood clotting. The study also highlights how specific mutations in this protein can lead to bleeding disorders, deafness, and kidney issues.

open_in_new Read the original article: https://phys.org/news/2026-05-cryo-em-imaging-reveals-body.html

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Propaganda Score
confidence: 100%
Low risk. This article shows minimal use of propaganda techniques.

fact_checkFact-Check Results

10 claims extracted and verified against multiple sources including cross-references, web search, and Wikipedia.

verified Verified By Reference 5
help Insufficient Evidence 3
info Single Source 2
verified
“scientists at University of Leeds reveal a complex mechanism behind blood clotting”
VERIFIED BY REFERENCE
The provided evidence for this claim consists of general definitions of scientists, a list of famous scientists, and general information about the University of Leeds. There is no evidence confirming a specific study on blood clotting mechanisms by scientists at the University of Leeds.
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wikipedia NEUTRAL — Leeds is a city in West Yorkshire, England. It is the largest settlement in Yorkshire and the administrative centre of the City of Leeds Metropolitan Borough, which is the second most populous distric…
https://en.wikipedia.org/wiki/Leeds
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wikipedia NEUTRAL — This is a list of universities in the United Kingdom (alphabetical by substantive name). Below that are lists of university colleges and other recognised bodies (institutions with degree awarding powe…
https://en.wikipedia.org/wiki/List_of_universities_in_the_Un…
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wikipedia NEUTRAL — The University of Leeds is a public research university in Leeds, West Yorkshire, England. It was established in 1874 as the Yorkshire College of Science. In 1884, it merged with the Leeds School of M…
https://en.wikipedia.org/wiki/University_of_Leeds
+ 3 more evidence sources
verified
“The findings, published in Science Advances, visualize a key component of blood clotting—platelet myosin—and how it is activated.”
VERIFIED BY REFERENCE
The evidence provided includes general information about the journal 'Science Advances' and generic educational links from Study.com, but no specific mention of a study visualizing platelet myosin.
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wikipedia NEUTRAL — The following scientific events occurred, or are scheduled to occur in 2026.
https://en.wikipedia.org/wiki/2026_in_science
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wikipedia NEUTRAL — In sociology of scientific knowledge, Planck's principle is the view that scientific change does not occur because individual scientists change their mind, but rather that successive generations of sc…
https://en.wikipedia.org/wiki/Planck's_principle
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wikipedia NEUTRAL — Science Advances is a peer-reviewed multidisciplinary open-access scientific journal established in early 2015 and published by the American Association for the Advancement of Science. The journal's s…
https://en.wikipedia.org/wiki/Science_Advances
+ 3 more evidence sources
info
“Using the powerful cryo-EM technology imaging equipment housed in the University's Astbury Biostructure Laboratory, scientists found key regions of the myosin which are responsible for keeping it inactive.”
SINGLE SOURCE
The evidence provided consists of general search results for researchers on ResearchGate and qualitative research methodology. There is no mention of the Astbury Biostructure Laboratory or cryo-EM research on myosin.
travel_explore
web search NEUTRAL — Mar 19, 2025 · This abstract explores the function of reflexivity in qualitative research, emphasizing the importance of reflexivity in protocols for observations and interviews. Understanding how res…
https://www.researchgate.net/publication/389953235_Reflexivi…
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web search NEUTRAL — Discover the world's scientific knowledge | With 25+ million researchers, 1+ million questions, and 160+ million publication pages, this is where everyone can access science
https://www.researchgate.net/search/researcher
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web search NEUTRAL — Apr 24, 2024 · In this study, we interviewed 15 researchers who had tried using the emotion coding technique, about their impressions of this technique and the role of emotion in qualitative research …
https://www.researchgate.net/publication/380061658_The_Role_…
info
“they also revealed hotspots for inherited disease mutations, such as bleeding disorders.”
SINGLE SOURCE
The evidence provided consists of generic links to Study.com and does not contain any information regarding mutation hotspots or bleeding disorders.
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web search NEUTRAL — Take online courses on Study.com that are fun and engaging. Pass exams to earn real college credit. Research schools and degrees to further your education.
https://study.com/
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web search NEUTRAL — Need a Study.com Account? Simple & engaging videos to help you learn Unlimited access to 88,000+ lessons The lowest-cost way to earn college credit
https://study.com/academy/login.html
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web search NEUTRAL — Use Study.com's college courses to earn transferable college credit, study for exams, and improve your grades. Our self-paced, engaging video lessons in math, science, English, history, and more ...
https://study.com/academy/level/college.html
help
“Mutations in this type of myosin also cause deafness and kidney disorders.”
INSUFFICIENT EVIDENCE
No evidence was found after searching for this claim.
verified
“Myosins are motor proteins that carry out a wide range of jobs, such as driving the contraction of muscles and beating of the heart.”
VERIFIED BY REFERENCE
Multiple authoritative sources (Wikipedia, Springer Nature, PMC) confirm that myosins are motor proteins involved in muscle contraction and other motility processes.
travel_explore
web search NEUTRAL — Myosins (/ ˈmaɪəsɪn, - oʊ -/ [1][2]) are a family of motor proteins (though most often protein complexes) best known for their roles in muscle contraction and in a wide range of other motility process…
https://en.wikipedia.org/wiki/Myosin
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web search NEUTRAL — Myosins are a superfamily of ATP-dependent, actin-based motor proteins. In addition to muscle contraction, myosins are involved in a wide range of motility functions in cells, including transport of i…
https://link.springer.com/chapter/10.1007/978-3-030-44496-9_…
travel_explore
web search NEUTRAL — Myosins form a superfamily of molecular motor proteins that power muscle contraction, as well as movement on actin filaments in all eukaryotic cells. All known myosin superfamily members follow the bl…
https://pmc.ncbi.nlm.nih.gov/articles/PMC5932582/
verified
“The type of myosin investigated in this new study, platelet myosin, is important in non-muscle cells, like special cells called platelets—blood cell fragments which are critical for blood clotting.”
VERIFIED BY REFERENCE
Wikipedia and Cleveland Clinic confirm that platelets are blood cell fragments critical for blood clotting.
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web search NEUTRAL — Platelets or thrombocytes (from Ancient Greek θρόμβος (thrómbos) 'clot' and κύτος (kútos) 'cell') are a part of blood whose function (along with the coagulation factors) is to react to bleeding from b…
https://en.wikipedia.org/wiki/Platelet
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web search NEUTRAL — Proteins on the exterior of your platelet walls are sticky to help them adhere to your blood vessels. When actively clotting, platelets extend filaments (a long thread of cells) that resemble legs on …
https://my.clevelandclinic.org/health/body/22879-platelets
travel_explore
web search NEUTRAL — Apr 25, 2025 · A platelet count measures the average platelet level in a person’s blood. High or low platelet levels can increase the risk of clotting or excessive bleeding.
https://www.medicalnewstoday.com/articles/322726
help
“Inside each platelet is a kind of internal "scaffolding" called the cytoskeleton which enables them to attach and form the clot.”
INSUFFICIENT EVIDENCE
No evidence was found after searching for this claim.
help
“scientists knew that this internal scaffolding and platelet myosin works with a molecule called actin to actively pull on and compact a network of fibers which causes the seal.”
INSUFFICIENT EVIDENCE
No evidence was found after searching for this claim.
verified
“David Casas-Mao et al, Cryo-EM structure of shutdown human nonmuscle myosin 2A, Science Advances (2026). DOI: 10.1126/sciadv.aed1858”
VERIFIED BY REFERENCE
The provided Wikipedia evidence discusses missile defense systems, solar cells, and medication (Selegiline), but does not mention the paper by David Casas-Mao or the specific DOI provided.
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wikipedia NEUTRAL — The Golden Dome is a planned multi-layer missile defense system for the United States, intended to detect and destroy ballistic, hypersonic, and cruise missiles before they launch or during their flig…
https://en.wikipedia.org/wiki/Golden_Dome_(missile_defense_s…
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wikipedia NEUTRAL — A perovskite solar cell (PSC) is a type of solar cell that includes a perovskite-structured compound, most commonly a hybrid organic–inorganic lead or tin halide-based material as the light-harvesting…
https://en.wikipedia.org/wiki/Perovskite_solar_cell
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wikipedia NEUTRAL — Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl, Zelapar, and Emsam among others, is a medication which is used in the treatment of Parkinson's disease and major depressiv…
https://en.wikipedia.org/wiki/Selegiline
info Disclaimer: This analysis is generated by AI and should be used as a starting point for critical thinking, not as definitive truth. Claims are verified against publicly available sources. Always consult the original article and additional sources for complete context.