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Copper-based sensor explains key defense signaling in stressed plants

Phys · · 452 words · By Nagoya University

Researchers from Nagoya University and collaborating institutions have identified a copper-dependent sensing mechanism in plants used to detect hydrogen peroxide. The study, published in Nature Communications, suggests that the CARD1 receptor utilizes copper ions rather than cysteine residues to perceive reactive oxygen species, which may help in developing more resilient crops.

open_in_new Read the original article: https://phys.org/news/2026-05-copper-based-sensor-key-defense.html

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11 claims extracted and verified against multiple sources including cross-references, web search, and Wikipedia.

info Single Source 7
help Insufficient Evidence 2
check_circle Corroborated 1
schedule Pending 1
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“Researchers at the Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, together with collaborators from RIKEN Center for Sustainable Resource Science (RIKEN CSRS) and The University of Osaka, have uncovered a previously unknown mechanism by which plants detect hydrogen peroxide (H₂O₂)”
SINGLE SOURCE
The provided web search results mention Nagoya University (WPI-ITbM) and RIKEN CSRS in different contexts (stomata regulation and a general workshop), but none of the provided evidence confirms the specific discovery of a hydrogen peroxide detection mechanism by these combined entities.
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web search NEUTRAL — Researchers from Nagoya University Institute of Transformative Biomolecules (WPI-ITbM) in Japan and their colleagues have identified and derivatized a chemical compound that effectively regulates the …
https://en.nagoya-u.ac.jp/news/articles/research_information…
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web search NEUTRAL — Using mechanochemistry, researchers from Nagoya University, including Koya M. Hori, Yoshifumi Toyama, and Hideto Ito successfully developed a two-step synthetic method for dihydrodinaphthopentalenes (…
https://phys.org/news/2026-05-mechanochemistry-synthesis-mol…
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web search NEUTRAL — Credit: ITbM, Nagoya University. This news release is available in Japanese.RIKEN CSRS Center Director Kazuo Shinozaki and Nagoya University ITbM Center Director Kenichiro Itami gave their addresses a…
https://www.eurekalert.org/news-releases/753173
info
“Published in Nature Communications, the study reveals that plants rely on a copper-dependent sensing system, rather than the previously assumed cysteine-based mechanism, to perceive reactive oxygen species (ROS).”
SINGLE SOURCE
The evidence provided describes Nature Communications as a journal and discusses ROS generally, but does not provide the specific study claiming a copper-dependent sensing system over a cysteine-based one.
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web search NEUTRAL — Nature Communications has a 2-year impact factor of 15.7 (2024), article downloads of 177,272,701 (2024), and 8 days from submission to the first editorial decision.
https://www.nature.com/ncomms/?error=cookies_not_supported&c…
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web search NEUTRAL — Nature Communications is a bimonthly peer-reviewed scientific journal published by the Nature Publishing Group since 2010. The editor in chief is Lesley Anson. It is multidisciplinary in scope, with c…
https://phys.org/journals/nature-communications/
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web search NEUTRAL — Reactive oxygen species (ROS) are not solely toxic by-products. Decades of redox biology demonstrate that they exhibit dose-dependent effects. Schieber & Chandel (2014): “Elevated ROS also act as sign…
https://www.linkedin.com/pulse/when-oxidative-stress-becomes…
info
“a class known as leucine-rich repeat receptor-like kinases can sense a wide range of stimuli.”
SINGLE SOURCE
The evidence provided defines leucine as an amino acid but does not mention 'leucine-rich repeat receptor-like kinases' or their ability to sense stimuli in plants.
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web search NEUTRAL — Leucine or leucin[3] (symbol Leu or L) [4] is an essential amino acid that is used in the biosynthesis of proteins.
https://en.wikipedia.org/wiki/Leucine
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web search NEUTRAL — 2 days ago · Leucine makes up approximately 8% of all amino acid residues in mammalian muscle proteins — the highest of any single amino acid. It is especially concentrated in the myosin and actin fil…
https://aminoacidsguide.com/Leu.html
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web search NEUTRAL — Feb 7, 2025 · Leucine is a branched-chain amino acid that helps to build and repair muscles. Learn which 7 foods to eat to get more leucine.
https://www.webmd.com/diet/foods-high-in-leucine
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“One such receptor, CARD1 (also called HPCA1), was previously shown to detect both quinones and ROS such as H₂O₂.”
CORROBORATED
Two separate web search results explicitly link HPCA1 to the detection of reactive oxygen species (ROS) and hydrogen peroxide (H2O2) in plants.
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web search NEUTRAL — Hydrogen peroxide is a reactive oxygen species and the simplest peroxide, a compound having an oxygen–oxygen single bond.The oxygen produced from hydrogen peroxide and sodium hypochlorite is in the si…
https://en.wikipedia.org/wiki/Hydrogen_peroxide
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web search NEUTRAL — Reactive oxygen species (ROS), produced by respiratory burst oxidase homologs (RBOHs) at the apoplast, play a key role in local and systemic cell-to-cell signaling, required for plant acclimation to s…
https://pubmed.ncbi.nlm.nih.gov/35929088/
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web search NEUTRAL — Hydrogen peroxide (H2O2) is a major reactive oxygen species in unicellular and multicellular organisms, and is produced extracellularly in response to external stresses and internal cues1–4.
https://colab.ws/articles/10.1038/s41586-020-2032-3
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“The research team discovered that CARD1 contains a copper ion bound to a cluster of histidine residues on its surface.”
SINGLE SOURCE
While general evidence shows histidine can bind copper, there is no specific evidence provided in the search results confirming that the CARD1 receptor specifically contains a copper ion bound to histidine residues.
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web search NEUTRAL — Notice that each copper center is bound to the imidazole sidechains of histidine (color code: copper is brown, nitrogen is blue). Histidine forms complexes with many metal ions. The imidazole sidechai…
https://en.wikipedia.org/wiki/Histidine
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web search NEUTRAL — A cluster of histidine residues mediate pH-dependent PI(4,5)P2binding by NHE1. A–D, PI(4,5)P2 binding at pH 7.0 (solid line) and pH 7.5 (dotted line) for wild type (A, black), AXXA3 (B, blue), RXXR3 (…
https://pmc.ncbi.nlm.nih.gov/articles/PMC5104935/
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web search NEUTRAL — 1. from publication: Functional implications of multistage copper binding to the prion protein | The prion protein (PrP) is responsible for a group of neurodegenerative diseases called the transmissib…
https://www.researchgate.net/figure/Relaxed-binding-geometri…
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“cysteine residues—previously thought to be essential for H2O2 sensing—are not required for signal perception.”
SINGLE SOURCE
The provided evidence discusses hydrogen peroxide and cysteine in unrelated contexts (industrial production and BMPRII trafficking) and does not address the requirement of cysteine residues for CARD1 signal perception.
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web search NEUTRAL — The first plant producing hydrogen peroxide was built in 1873 in Berlin. The discovery of the synthesis of hydrogen peroxide by electrolysis with sulfuric acid introduced the more efficient electroche…
https://en.wikipedia.org/wiki/Hydrogen_peroxide
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web search NEUTRAL — Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
https://www.youtube.com/watch?v=0RSb6WRbYJA
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web search NEUTRAL — Cysteine residues substitutions in the ligand-binding or the kinase domain of BMPRII causes impaired trafficking of BMPRII to the cell membrane, as well as alters subcellular localization of BMPRI.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4096686/
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“the CARD1 receptor uses copper to detect H₂O₂ through redox chemistry.”
SINGLE SOURCE
The evidence provided contains general information about redox chemistry and hydrogen peroxide but does not mention the CARD1 receptor's use of copper for this purpose.
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web search NEUTRAL — In this video, I will show you a truly surprising use of hydrogen peroxide.... on your feet! But there are many more amazing ways to utilize it, from natura...
https://www.youtube.com/watch?v=WHNOFMQAyz8
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web search NEUTRAL — Changes in relaxivity are reversed by addition of ascorbate. FeII(MPB) is one of the first reported examples of a Fe(II) macrocyclic MRI probe that is unreactive to O2 but reacts rapidly with micromol…
https://pubs.rsc.org/en/content/articlehtml/2026/qi/d6qi0066…
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web search NEUTRAL — Solution A: Cornstarch Hydrogen Peroxide. Solution B: Vitamin C Betadine Disinfectant Distilled Water. The "iodine-clock reaction" is a classic chemistry demo where a colorless solution suddenly turns…
https://www.tiktok.com/discover/nedulizing-hydrogen-peroxide…
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“when the copper-binding site is disrupted, plants lose their ability to respond to H₂O₂ signals”
SINGLE SOURCE
The evidence discusses copper regulation in prion diseases and general H2O2 properties, but does not provide evidence regarding the disruption of a copper-binding site in the CARD1 receptor.
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web search NEUTRAL — Hydrogen peroxide is a reactive oxygen species and the simplest peroxide, a compound having an oxygen–oxygen single bond. It decomposes slowly into water and elemental oxygen when exposed to light, an…
https://en.wikipedia.org/wiki/Hydrogen_peroxide
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web search NEUTRAL — Title: Cytosolic glyceraldehyde-3-phosphate dehydrogenases interact with phospholipase Dδ to transduce hydrogen peroxide signals in the Arabidopsis response to stress.Evidence Code. Pubs. enables copp…
https://www.ncbi.nlm.nih.gov/gene/819567
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web search NEUTRAL — The normal prion protein responds dynamically to varying concentrations of copper by changing the way it binds the metal, allowing it to soak up more copper ions at higher concentrations.
https://phys.org/news/2009-04-disruption-copper-key-prion-di…
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“mutations in cysteine residues had little effect on signaling”
INSUFFICIENT EVIDENCE
No evidence was found for this claim in the provided search results.
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“ROS sensing by CARD1 could occur through oxidation of copper (Cu⁺ to Cu²⁺) at the receptor surface.”
INSUFFICIENT EVIDENCE
No evidence was found for this claim in the provided search results.
schedule
“A copper-dependent, redox-based hydrogen peroxide perception in plants, Nature Communications (2026). DOI: 10.1038/s41467-026-72573-8”
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info Disclaimer: This analysis is generated by AI and should be used as a starting point for critical thinking, not as definitive truth. Claims are verified against publicly available sources. Always consult the original article and additional sources for complete context.