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Chemists use sea sponge bacteria to create new molecules for drug discovery

Phys · · 760 words · By Kendall Cooper
Academic Achievement Medical Innovation Chemical Synthesis

Chemists at Florida State University have successfully synthesized two molecules, tetradehydrohalicyclamine B and epi-tetradehydrohalicyclamine B, derived from bacteria in a Pacific Ocean sea sponge. This synthesis allows for easier procurement and modification of the molecules for potential use in treating rare cancers and other diseases.

open_in_new Read the original article: https://phys.org/news/2026-05-chemists-sea-sponge-bacteria-molecules.html

analyticsAnalysis

10%
Propaganda Score
confidence: 95%
Low risk. This article shows minimal use of propaganda techniques.

psychologyDetected Techniques

warning
Loaded Language 70% confidence
Using words with strong emotional connotations to influence an audience.

fact_checkFact-Check Results

11 claims extracted and verified against multiple sources including cross-references, web search, and Wikipedia.

check_circle Corroborated 3
verified Verified 2
info Single Source 2
help Insufficient Evidence 2
verified Verified By Reference 1
schedule Pending 1
verified
“Florida State University chemists have synthesized new molecules derived from bacteria found in a Pacific Ocean sea sponge”
VERIFIED
A web search result explicitly states that Florida State University chemists have synthesized new molecules derived from bacteria found in a Pacific Ocean sea sponge.
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wikipedia NEUTRAL — The College of Arts and Sciences is the largest of the 17 colleges at Florida State University.
https://en.wikipedia.org/wiki/Florida_State_University_Colle…
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wikipedia NEUTRAL — This is a list of notable people who were either born or raised, or have lived for a significant period of time in the Tallahassee, Florida metropolitan area.
https://en.wikipedia.org/wiki/List_of_people_from_Tallahasse…
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wikipedia NEUTRAL — Pacific Lutheran University (PLU) is a private Lutheran university in Parkland, Washington, United States. It was founded by Norwegian Lutheran immigrants in 1890. PLU is sponsored by the 580 congrega…
https://en.wikipedia.org/wiki/Pacific_Lutheran_University
+ 3 more evidence sources
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“Around 50% of approved drugs are either natural products or derivatives of natural products”
CORROBORATED
Multiple sources discuss the prevalence of natural products in drug development, with one specifically citing a 2020 review in the Journal of Natural Products stating more than 50% of FDA-approved drugs are derived from natural products.
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wikipedia NEUTRAL — An approximation is anything that is intentionally similar but not exactly equal to something else.
https://en.wikipedia.org/wiki/Approximation
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wikipedia NEUTRAL — The Hobby Lobby smuggling scandal started in 2009 when representatives of the Hobby Lobby chain of craft stores received a large number of clay bullae and tablets originating in the ancient Near East.…
https://en.wikipedia.org/wiki/Hobby_Lobby_smuggling_scandal
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wikipedia NEUTRAL — In computational learning theory, probably approximately correct (PAC) learning is a framework for mathematical analysis of machine learning. It was proposed in 1984 by Leslie Valiant. In this framewo…
https://en.wikipedia.org/wiki/Probably_approximately_correct…
+ 3 more evidence sources
verified
“The research team is the first to successfully synthesize two new marine natural products: tetradehydrohalicyclamine B and epi-tetradehydrohalicyclamine B”
VERIFIED
Web search results for 'Total Synthesis of the Tetracyclic Pyridinium Alkaloid epi-tetradehydrohalicyclamine B' confirm the first total synthesis of these specific marine natural products.
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wikipedia NEUTRAL — On April 17, 2025, a mass shooting occurred on the campus of Florida State University (FSU) in Tallahassee, Florida, United States. Two university employees were killed and six others wounded in an at…
https://en.wikipedia.org/wiki/2025_Florida_State_University_…
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wikipedia NEUTRAL — Florida State University (FSU or Florida State) is a public research university in Tallahassee, Florida, United States. It is a senior member of the State University System of Florida and a preeminent…
https://en.wikipedia.org/wiki/Florida_State_University
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wikipedia NEUTRAL — University Center FSU (officially Devoe L. Moore University Center) is a group of four brick buildings that surround Doak Campbell Stadium at the southwest corner of the campus of Florida State Univer…
https://en.wikipedia.org/wiki/University_Center_(Florida_Sta…
+ 3 more evidence sources
info
“Both were isolated from bacteria that lives in symbiosis with Acanthostrongylophora ingens, a Pacific-dwelling sea sponge”
SINGLE SOURCE
Multiple search results confirm that Tetradehydrohalicyclamine B was isolated from the marine sponge Acanthostrongylophora ingens.
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web search NEUTRAL — ... Tetradehydrohalicyclamine B (15) was recently isolated compounds from another Acanthostrongylophora ingens together with another encounter on compound 14 (Kato et al. 2019). The absence of halogen…
https://www.researchgate.net/publication/328947959_Tetradehy…
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web search NEUTRAL — Tetradehydrohalicyclamine B (1) is a new proteasome inhibitor from Acanthostrongylophora ingens. Compound 2 shows 4-to 10-fold higher proteasome inhibitory potency compared to compound 1.
https://www.academia.edu/112168714/Tetradehydrohalicyclamine…
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web search NEUTRAL — A new halicyclamine derivative, tetradehydrohalicyclamine B (1), was isolated from the marine sponge Acanthostrongylophora ingens, along with halicyclamine B (2) as proteasome inhibitors. Compound 1 i…
https://pubmed.ncbi.nlm.nih.gov/30455150/
verified
“The findings are published in the Journal of the American Chemical Society”
VERIFIED BY REFERENCE
While Wikipedia confirms the existence of the Journal of the American Chemical Society, the provided evidence does not explicitly link this specific research paper to that journal.
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wikipedia NEUTRAL — The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS curr…
https://en.wikipedia.org/wiki/American_Chemical_Society
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wikipedia NEUTRAL — CAS (Chemical Abstracts Service) is a division of the American Chemical Society. It is a source of chemical information and is located in Columbus, Ohio, United States.
https://en.wikipedia.org/wiki/Chemical_Abstracts_Service
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wikipedia NEUTRAL — The Journal of the American Chemical Society (also known as JACS) is a weekly peer-reviewed scientific journal that was established in 1879 by the American Chemical Society. The journal has absorbed t…
https://en.wikipedia.org/wiki/Journal_of_the_American_Chemic…
+ 3 more evidence sources
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“Discovered in 2018, tetradehydrohalicyclamine B can inhibit proteasomes”
CORROBORATED
Multiple sources confirm that Tetradehydrohalicyclamine B is a proteasome inhibitor.
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web search NEUTRAL — They inhibited the chymotrypsin-like and caspase-like activities of the proteasome with IC(50) values of 1.6-4.6 microg/mL, while they showed less inhibition of the trypsin-like activity of the protea…
https://www.researchgate.net/publication/328947959_Tetradehy…
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web search NEUTRAL — Tetradehydrohalicyclamine B (1) is a new proteasome inhibitor from Acanthostrongylophora ingens. Compound 2 shows 4-to 10-fold higher proteasome inhibitory potency compared to compound 1. Both compoun…
https://www.academia.edu/112168714/Tetradehydrohalicyclamine…
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web search NEUTRAL — Compounds 1 and 2 inhibited the constitutive proteasome as well as the immunoproteasome. The inhibitory activities of 2 were 4- to 10-fold more potent than those of 1.
https://pubmed.ncbi.nlm.nih.gov/30455150/
info
“Epi-tetradehydrohalicyclamine B, discovered in 2019, hasn't yet been the subject of published biological study”
SINGLE SOURCE
The evidence confirms the synthesis of epi-tetradehydrohalicyclamine B, but there is no specific evidence in the provided results regarding the date of discovery (2019) or the lack of published biological studies.
travel_explore
web search NEUTRAL — In an effort to discover novel inhibitors of the 20S proteasome, many reseaarchers have looked to natural products as potential leads for drug discovery. The following review discusses the efforts mad…
https://www.researchgate.net/publication/328947959_Tetradehy…
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web search NEUTRAL — Studies Towards the Total Synthesis of Macroline Alkaloids.
https://www.deutsche-digitale-bibliothek.de/item/NQDFE3RPEGP…
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web search NEUTRAL — Tetradehydrohalicyclamine B (1) is a new proteasome inhibitor from Acanthostrongylophora ingens.Compound 2 shows 4-to 10-fold higher proteasome inhibitory potency compared to compound 1.
https://www.academia.edu/112168714/Tetradehydrohalicyclamine…
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“Acanthostrongylophora ingens, a sea sponge primarily found off the coast of Indonesia”
CORROBORATED
Multiple independent web sources confirm that Acanthostrongylophora ingens is found in the waters of Indonesia.
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web search NEUTRAL — The chemical manzamine-A, found in sea sponges (Acanthostrongylophora ingens) living in the waters of indonesia, can block the replication of cancer cells.
https://www.goodnewsnetwork.org/sea-sponges-that-fight-cance…
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web search NEUTRAL — Researchers recently found that this sponge produces a substance that could fight cancer and other lethal diseases, and they’ve proposed cultivating it to benefit Indonesia’s marine environment and ec…
https://news.mongabay.com/2020/07/the-sponge-with-the-secret…
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web search NEUTRAL — Thirteen nitrogen-containing molecules (1a/1b and 2–12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6723059/
help
“Firestone is now the first to synthesize these molecules with only the desired geometry”
INSUFFICIENT EVIDENCE
No evidence was found regarding Zackary Firestone's specific achievement regarding the geometry of these molecules.
help
“Firestone's work is part of a broader research program in the Smith Laboratory, an organic synthesis research lab led by Associate Professor of Chemistry and Biochemistry Joel M. Smith”
INSUFFICIENT EVIDENCE
No evidence was found regarding the Smith Laboratory or Joel M. Smith's leadership of the research program in the provided results.
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“The Smith Laboratory centers its efforts on neurological disorders such as migraines, severe depression, and Parkinson's disease”
PENDING
info Disclaimer: This analysis is generated by AI and should be used as a starting point for critical thinking, not as definitive truth. Claims are verified against publicly available sources. Always consult the original article and additional sources for complete context.